![The NLRP3 inflammasome: molecular activation and regulation to therapeutics | Nature Reviews Immunology The NLRP3 inflammasome: molecular activation and regulation to therapeutics | Nature Reviews Immunology](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41577-019-0165-0/MediaObjects/41577_2019_165_Fig1_HTML.png)
The NLRP3 inflammasome: molecular activation and regulation to therapeutics | Nature Reviews Immunology
![INFLAMMASOME INHIBITORS - 21st Century Miracle Drugs: Spotlight on Clinical NLRP3 Inflammasome Inhibitors INFLAMMASOME INHIBITORS - 21st Century Miracle Drugs: Spotlight on Clinical NLRP3 Inflammasome Inhibitors](https://d2akihtr51eb46.cloudfront.net/wp-content/uploads/2023/04/F1-5.jpg)
INFLAMMASOME INHIBITORS - 21st Century Miracle Drugs: Spotlight on Clinical NLRP3 Inflammasome Inhibitors
PKD-mediated NLRP3 activation pathway and the relevant CAPS mutations.... | Download Scientific Diagram
![Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease - ScienceDirect Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0753332221002274-ga1.jpg)
Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease - ScienceDirect
![Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases | Science Immunology Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases | Science Immunology](https://www.science.org/cms/10.1126/sciimmunol.abe2933/asset/19b6dbb0-b8e8-4bf8-9e7c-f9aaf06a1f72/assets/graphic/abe2933-f2.jpeg)
Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases | Science Immunology
![Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model - eBioMedicine Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model - eBioMedicine](https://www.thelancet.com/cms/attachment/c52a0741-4e57-44e2-b29a-f045cd82a5db/gr1_lrg.jpg)
Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model - eBioMedicine
![Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications - eBioMedicine Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications - eBioMedicine](https://www.thelancet.com/cms/attachment/71d419d6-f3d1-456b-a5f9-e1106476d2c6/gr1_lrg.jpg)
Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications - eBioMedicine
The NLRP3/NEK7 complex domains and related CAPS mutations. A 3D cartoon... | Download Scientific Diagram
![Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome | eLife Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome | eLife](https://iiif.elifesciences.org/lax/75166%2Felife-75166-fig4-v2.tif/full/1500,/0/default.jpg)
Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome | eLife
![T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells | Science T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells | Science](https://www.science.org/cms/10.1126/science.aad1210/asset/b27c2d3c-a3c3-4aae-80ca-d1902cfd0063/assets/graphic/352_aad1210_fa.jpeg)
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells | Science
![NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome - Journal of Allergy and Clinical Immunology NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome - Journal of Allergy and Clinical Immunology](https://www.jacionline.org/cms/asset/26777c1d-bff0-4d72-a1bf-1d03805bde3f/gr3.jpg)
NLRP3 leucine-rich repeats control induced and spontaneous inflammasome activation in cryopyrin-associated periodic syndrome - Journal of Allergy and Clinical Immunology
![Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity | Journal of Medicinal Chemistry Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.0c01743/asset/images/large/jm0c01743_0008.jpeg)
Berberine Directly Targets the NEK7 Protein to Block the NEK7–NLRP3 Interaction and Exert Anti-inflammatory Activity | Journal of Medicinal Chemistry
![Cells | Free Full-Text | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases Cells | Free Full-Text | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases](https://www.mdpi.com/cells/cells-11-01188/article_deploy/html/images/cells-11-01188-g001.png)
Cells | Free Full-Text | Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases
![Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders | Arteriosclerosis, Thrombosis, and Vascular Biology Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders | Arteriosclerosis, Thrombosis, and Vascular Biology](https://www.ahajournals.org/cms/asset/ab91cdfc-8233-40d6-a196-725c52a7c515/2765ga1.jpg)